BCR-Assosiated Kinase Inhibition in Relapsed/Refractory Chronic Lymphocytic Leukemia. Real World Experiences of a German Regional Clinical Register
نویسندگان
چکیده
منابع مشابه
The role of microRNA in acute/chronic, myeloid/lymphocytic leukemia
MicroRNAs are small, non-coding sequences that regulate gene expression by inducing degradation or translational inhibition of target mRNAs. These molecules control many intracellular physiological and pathological processes.Abnormal expression of these moleculs has been described in different cancers including hematopoietic cancers. According to the type of cancer and the stage, miRNA’s expres...
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PI3K signaling is now targeted in first clinical trials in patients with B cell malignancies, including Chronic Lymphocytic Leukemia (CLL), which represent one of the first molecularly targeted therapies for B cell malignancies.
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B-cell antigen receptor (BCR)-mediated signaling plays a critical role in chronic lymphocytic leukemia (CLL) pathogenesis and gives an in vitro survival advantage to B cells isolated from patients with unfavorable prognostic factors. In this study, we undertook to elucidate the signaling intermediates responsible for this biologic alteration. In responding cells only, in vitro BCR engagement tr...
متن کاملLYMPHOID NEOPLASIA The degree of BCR and NFAT activation predicts clinical outcomes in chronic lymphocytic leukemia
1Inserm U978, Bobigny, France; 2Université Paris 13, Sorbonne Paris Cité, “Adaptateurs de Signalisation en Hématologie,” Labex “Inflamex,” Unité de Formation et de Recherche Santé-Médecine-Biologie Humaine, Bobigny, France; 3Hôpital Avicenne, Assistance Publique–Hôpitaux de Paris (AP-HP), Service d’Hématologie Biologique, Bobigny, France; and 4Hôpital Avicenne, AP-HP, Unité de Recherche Cliniqu...
متن کاملChronic lymphocytic leukemia: a clinical review.
IMPORTANCE The most common leukemia is chronic lymphocytic leukemia (CLL). Every year, there are 15 000 new diagnoses and 5000 CLL deaths in the United States. Although therapeutic choices were once limited, treatment of this disease has vastly improved in the last decade. OBJECTIVE Evidence-based review of the diagnosis, staging, and treatment of CLL. EVIDENCE REVIEW PubMed, Cochrane Libra...
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ژورنال
عنوان ژورنال: Blood
سال: 2020
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2020-134686